Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Cyclophosphamide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may increase the myelosuppression caused by cyclophosphamide, leading to deeper or longer neutropenia. The effect is reported mainly from pharmacological data and is usually manageable with blood count monitoring.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Cyclophosphamide belongs to Oncology.
Why it happens
Hydrochlorothiazide may reduce renal clearance of cyclophosphamide or its metabolites, increasing exposure and bone marrow toxicity.
What to do
Monitor complete blood counts closely during chemotherapy. Consider an alternative to the thiazide if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Cyclophosphamide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may increase the myelosuppression caused by cyclophosphamide, leading to deeper or longer neutropenia. The effect is reported mainly from pharmacological data and is usually manageable with blood count monitoring.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during chemotherapy. Consider an alternative to the thiazide if marked myelosuppression occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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