Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Deflazacort
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and corticosteroids such as deflazacort both promote potassium loss, so hypokalemia may be more pronounced. Hypokalemia can cause muscle weakness and arrhythmias.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from thiazide diuresis and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium periodically and replace potassium or adjust therapy when levels fall. The olmesartan component partly offsets potassium loss.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Deflazacort?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide and corticosteroids such as deflazacort both promote potassium loss, so hypokalemia may be more pronounced. Hypokalemia can cause muscle weakness and arrhythmias.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically and replace potassium or adjust therapy when levels fall. The olmesartan component partly offsets potassium loss.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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