Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Dexamethasone
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone and hydrochlorothiazide both lower potassium, raising hypokalemia risk. Dexamethasone also induces CYP3A4 and may reduce amlodipine levels, and it can raise blood pressure through fluid retention.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Dexamethasone belongs to Endocrine.
Why it happens
Additive potassium loss, plus corticosteroid-mediated CYP3A4 induction and sodium retention.
What to do
Monitor serum potassium and blood pressure during systemic dexamethasone therapy, and replace potassium or adjust antihypertensives as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Dexamethasone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone and hydrochlorothiazide both lower potassium, raising hypokalemia risk. Dexamethasone also induces CYP3A4 and may reduce amlodipine levels, and it can raise blood pressure through fluid retention.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during systemic dexamethasone therapy, and replace potassium or adjust antihypertensives as needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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