Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Dobutamine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine can cause a shift of potassium into cells through beta-2 stimulation, and hydrochlorothiazide causes renal potassium loss. Together they may produce clinically significant hypokalemia and arrhythmias in monitored settings.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Dobutamine belongs to Cardiovascular.
Why it happens
Additive lowering of serum potassium through beta-2 mediated cellular uptake and thiazide kaliuresis.
What to do
Monitor serum potassium and ECG during dobutamine infusion and replace potassium as needed. Consider holding the diuretic in acute care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Dobutamine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine can cause a shift of potassium into cells through beta-2 stimulation, and hydrochlorothiazide causes renal potassium loss. Together they may produce clinically significant hypokalemia and arrhythmias in monitored settings.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dobutamine infusion and replace potassium as needed. Consider holding the diuretic in acute care.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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