Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Efavirenz
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Efavirenz: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can induce CYP3A4 and may lower amlodipine concentrations. This may reduce blood pressure control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, increasing amlodipine metabolism.
What to do
Monitor blood pressure after efavirenz is started or stopped and increase the amlodipine dose if control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Efavirenz?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz can induce CYP3A4 and may lower amlodipine concentrations. This may reduce blood pressure control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Efavirenz?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after efavirenz is started or stopped and increase the amlodipine dose if control is inadequate.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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