Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Enoxaparin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including enoxaparin, can suppress aldosterone and cause hyperkalemia. Together with olmesartan, the risk is raised, particularly in renal impairment or diabetes.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-related inhibition of aldosterone synthesis adds to angiotensin receptor blockade, reducing potassium excretion.
What to do
Monitor serum potassium and renal function, especially if enoxaparin is used for more than a few days or in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Enoxaparin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including enoxaparin, can suppress aldosterone and cause hyperkalemia. Together with olmesartan, the risk is raised, particularly in renal impairment or diabetes.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially if enoxaparin is used for more than a few days or in at-risk patients.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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