Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Insulin degludec
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effect of insulin in diabetic patients. Olmesartan may conversely increase insulin sensitivity, so glycemic control can change after starting the combination.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazides impair glucose tolerance, partly through hypokalemia-related reduced insulin secretion and increased insulin resistance.
What to do
Monitor blood glucose and potassium after starting or changing the combination. Adjust the insulin dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Insulin degludec?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effect of insulin in diabetic patients. Olmesartan may conversely increase insulin sensitivity, so glycemic control can change after starting the combination.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting or changing the combination. Adjust the insulin dose if control worsens.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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