Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Istradefylline
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg daily raises exposure to CYP3A4 substrates, which may increase amlodipine levels and its vasodilatory effects. The effect was not seen at 20 mg daily.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline weakly inhibits CYP3A4 at higher doses, reducing amlodipine metabolism.
What to do
Monitor blood pressure and edema if istradefylline 40 mg is used. Consider reducing the amlodipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Istradefylline?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg daily raises exposure to CYP3A4 substrates, which may increase amlodipine levels and its vasodilatory effects. The effect was not seen at 20 mg daily.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema if istradefylline 40 mg is used. Consider reducing the amlodipine dose if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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