Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Meloxicam
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Meloxicam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam can attenuate the antihypertensive effect of olmesartan and hydrochlorothiazide, and the combination of an NSAID, an angiotensin receptor blocker and a thiazide diuretic (the so-called triple whammy) increases the risk of acute kidney injury and hyperkalemia. Older and volume-depleted patients are at highest risk.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and afferent arteriolar constriction, which combined with angiotensin II blockade and diuresis impairs glomerular filtration.
What to do
Avoid or minimize NSAID use and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, especially in the first weeks.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Meloxicam?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Meloxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Meloxicam can attenuate the antihypertensive effect of olmesartan and hydrochlorothiazide, and the combination of an NSAID, an angiotensin receptor blocker and a thiazide diuretic (the so-called triple whammy) increases the risk of acute kidney injury and hyperkalemia. Older and volume-depleted patients are at highest risk.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Meloxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or minimize NSAID use and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium, especially in the first weeks.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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