Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Naproxen
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Naproxen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can reduce the antihypertensive efficacy of olmesartan and hydrochlorothiazide, and the combination of an NSAID, ARB and diuretic increases the risk of acute kidney injury and hyperkalemia, particularly in older or dehydrated patients.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduces glomerular perfusion when combined with angiotensin blockade and diuresis.
What to do
Avoid regular NSAID use where possible, or use the lowest effective dose for the shortest time with adequate hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Naproxen?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naproxen can reduce the antihypertensive efficacy of olmesartan and hydrochlorothiazide, and the combination of an NSAID, ARB and diuretic increases the risk of acute kidney injury and hyperkalemia, particularly in older or dehydrated patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Naproxen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible, or use the lowest effective dose for the shortest time with adequate hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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