Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Nifedipine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and nifedipine are both dihydropyridine calcium channel blockers, so taking them together gives duplicate therapy with additive vasodilation. This can cause hypotension, flushing, headache and peripheral edema without a meaningful gain in blood pressure control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation from two dihydropyridine calcium channel blockers, with a possible minor competition for CYP3A4 metabolism.
What to do
Avoid combining two dihydropyridine calcium channel blockers and keep a single agent. If both have been given, monitor blood pressure and edema and stop one of them.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Nifedipine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and nifedipine are both dihydropyridine calcium channel blockers, so taking them together gives duplicate therapy with additive vasodilation. This can cause hypotension, flushing, headache and peripheral edema without a meaningful gain in blood pressure control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridine calcium channel blockers and keep a single agent. If both have been given, monitor blood pressure and edema and stop one of them.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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