Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Nilotinib
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may raise amlodipine concentrations, increasing the risk of hypotension and edema. Nilotinib also prolongs the QT interval, and thiazide-induced hypokalemia or hypomagnesemia could add to that risk.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by nilotinib reduces amlodipine clearance, and diuretic-related electrolyte loss adds to QT risk.
What to do
Monitor blood pressure and edema and reduce the amlodipine dose if needed. Keep potassium and magnesium within normal ranges and monitor the ECG as recommended for nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Nilotinib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may raise amlodipine concentrations, increasing the risk of hypotension and edema. Nilotinib also prolongs the QT interval, and thiazide-induced hypokalemia or hypomagnesemia could add to that risk.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and reduce the amlodipine dose if needed. Keep potassium and magnesium within normal ranges and monitor the ECG as recommended for nilotinib.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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