Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Oxcarbazepine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak CYP3A4 inducer and may lower amlodipine concentrations, reducing blood pressure control. Oxcarbazepine can also cause hyponatremia, which may be additive with hydrochlorothiazide.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction lowers amlodipine exposure; additive sodium loss from both drugs.
What to do
Monitor blood pressure and serum sodium, and increase amlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Oxcarbazepine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak CYP3A4 inducer and may lower amlodipine concentrations, reducing blood pressure control. Oxcarbazepine can also cause hyponatremia, which may be additive with hydrochlorothiazide.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum sodium, and increase amlodipine dose if needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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