Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Prednisolone
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisolone with hydrochlorothiazide can increase potassium loss and cause hypokalemia. Glucocorticoids may also raise blood pressure and blood glucose, which counters therapy.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Prednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting; glucocorticoid-related sodium retention.
What to do
Monitor serum potassium and blood pressure, and replace potassium as needed during prolonged or high-dose steroid therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Prednisolone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisolone with hydrochlorothiazide can increase potassium loss and cause hypokalemia. Glucocorticoids may also raise blood pressure and blood glucose, which counters therapy.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and replace potassium as needed during prolonged or high-dose steroid therapy.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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