Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Propranolol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol adds to the blood pressure lowering effect of the combination, which is often intended but can cause excessive hypotension or bradycardia. Beta-blockers can also mask hypoglycemia, and hydrochlorothiazide may worsen glucose and lipid control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-blockade, vasodilation, angiotensin receptor blockade and volume reduction.
What to do
Monitor blood pressure, heart rate and potassium, and titrate doses gradually. Review the need for the combination in diabetic patients and in pregnancy, where the ARB component is contraindicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Propranolol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol adds to the blood pressure lowering effect of the combination, which is often intended but can cause excessive hypotension or bradycardia. Beta-blockers can also mask hypoglycemia, and hydrochlorothiazide may worsen glucose and lipid control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium, and titrate doses gradually. Review the need for the combination in diabetic patients and in pregnancy, where the ARB component is contraindicated.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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