Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Repaglinide
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics such as hydrochlorothiazide can raise blood glucose, especially at higher doses, which may partly offset the glucose-lowering effect of repaglinide. The effect is usually small at the low doses present in combination tablets.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Thiazides cause pharmacodynamic antagonism by reducing insulin secretion and peripheral insulin sensitivity, partly through potassium loss.
What to do
Monitor blood glucose and HbA1c when starting or changing the thiazide dose, and adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Repaglinide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics such as hydrochlorothiazide can raise blood glucose, especially at higher doses, which may partly offset the glucose-lowering effect of repaglinide. The effect is usually small at the low doses present in combination tablets.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or changing the thiazide dose, and adjust the antidiabetic regimen if control worsens.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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