Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Rufinamide
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and may modestly lower amlodipine exposure, potentially reducing blood pressure control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping rufinamide and adjust the amlodipine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Rufinamide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and may modestly lower amlodipine exposure, potentially reducing blood pressure control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping rufinamide and adjust the amlodipine dose if needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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