Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Salmeterol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salmeterol and hydrochlorothiazide can lower serum potassium, and the effect may be additive, particularly at high beta-agonist doses. Hypokalemia can promote arrhythmias, especially in patients with heart disease or hypoxia.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Beta-2 agonism drives potassium into cells while thiazides increase renal potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium in patients on regular or high-dose salmeterol and replace potassium as required. The olmesartan component may partially offset losses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Salmeterol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salmeterol and hydrochlorothiazide can lower serum potassium, and the effect may be additive, particularly at high beta-agonist doses. Hypokalemia can promote arrhythmias, especially in patients with heart disease or hypoxia.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on regular or high-dose salmeterol and replace potassium as required. The olmesartan component may partially offset losses.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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