Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Spironolactone
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan and spironolactone both raise serum potassium, which can cause clinically significant hyperkalemia, especially in renal impairment or diabetes. Hydrochlorothiazide lowers potassium and partly offsets this, but the net effect is unpredictable.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Additive potassium retention from angiotensin receptor blockade and aldosterone antagonism, partly offset by thiazide kaliuresis.
What to do
Monitor serum potassium and renal function at baseline, within the first weeks, and periodically thereafter. Adjust or stop spironolactone if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Spironolactone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olmesartan and spironolactone both raise serum potassium, which can cause clinically significant hyperkalemia, especially in renal impairment or diabetes. Hydrochlorothiazide lowers potassium and partly offsets this, but the net effect is unpredictable.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at baseline, within the first weeks, and periodically thereafter. Adjust or stop spironolactone if potassium rises.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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