Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Timolol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol, including absorption from eye drops in susceptible patients, adds to blood pressure lowering and can cause bradycardia or hypotension. Beta-blockers can also mask hypoglycemia, and hydrochlorothiazide may worsen glucose control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects of beta-blockade with vasodilation, angiotensin receptor blockade and volume reduction.
What to do
Monitor blood pressure and heart rate and adjust doses gradually. Use caution with glucose monitoring in diabetic patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Timolol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic timolol, including absorption from eye drops in susceptible patients, adds to blood pressure lowering and can cause bradycardia or hypotension. Beta-blockers can also mask hypoglycemia, and hydrochlorothiazide may worsen glucose control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust doses gradually. Use caution with glucose monitoring in diabetic patients.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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