Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Tolmetin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolmetin can blunt the blood pressure lowering effect of olmesartan and hydrochlorothiazide. In combination with a thiazide and an ARB, they raise the risk of acute kidney injury, particularly in elderly or volume-depleted patients, and may also promote hyperkalemia.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit synthesis of vasodilatory renal prostaglandins, reducing renal perfusion and sodium excretion and opposing the antihypertensive and natriuretic effects of ARBs and diuretics.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or stopping tolmetin, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Tolmetin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolmetin can blunt the blood pressure lowering effect of olmesartan and hydrochlorothiazide. In combination with a thiazide and an ARB, they raise the risk of acute kidney injury, particularly in elderly or volume-depleted patients, and may also promote hyperkalemia.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or stopping tolmetin, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic such as paracetamol.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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