Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Valganciclovir
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may reduce renal clearance of ganciclovir, the active form of valganciclovir, and raise exposure. Thiazide-related volume depletion and reduced renal function could add to this, increasing the risk of hematologic toxicity.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Valganciclovir belongs to Anti Virals.
Why it happens
Competition for renal tubular secretion via organic anion transporters and possible reduction in renal function.
What to do
Monitor renal function and complete blood counts during therapy and adjust the valganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Valganciclovir?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may reduce renal clearance of ganciclovir, the active form of valganciclovir, and raise exposure. Thiazide-related volume depletion and reduced renal function could add to this, increasing the risk of hematologic toxicity.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and complete blood counts during therapy and adjust the valganciclovir dose to creatinine clearance.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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