Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Valsartan
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Valsartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is an angiotensin receptor blocker and duplicates the olmesartan component of this triple combination. Dual ARB therapy gives no added benefit and raises the risk of hypotension, hyperkalemia, and renal dysfunction.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II receptor blockade causes additive hypotension, reduced glomerular filtration and potassium retention.
What to do
Avoid using two ARBs together; keep only one RAAS blocker. If the combination has occurred, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Valsartan?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valsartan is an angiotensin receptor blocker and duplicates the olmesartan component of this triple combination. Dual ARB therapy gives no added benefit and raises the risk of hypotension, hyperkalemia, and renal dysfunction.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together; keep only one RAAS blocker. If the combination has occurred, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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