Drug interactions
Amlodipine-perindopril + Protein a column
Severity: Contraindicated
Amlodipine-perindopril and Protein a column: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitor-treated patients undergoing protein A immunoadsorption have experienced anaphylactoid reactions, related to bradykinin accumulation.
What this interaction means in plain words
Amlodipine-perindopril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
ACE inhibition prevents bradykinin breakdown, so bradykinin accumulates during column exposure and triggers anaphylactoid reactions.
What to do
Stop perindopril well before the procedure (about 72 hours per labeling) and use another antihypertensive class meanwhile.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Protein a column, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
- Amlodipine-perindopril + Candesartan Major
Frequently asked questions
Can I take Amlodipine-perindopril with Protein a column?
MediHelp rates the interaction as contraindicated. Amlodipine-perindopril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. ACE inhibitor-treated patients undergoing protein A immunoadsorption have experienced anaphylactoid reactions, related to bradykinin accumulation.
How serious is the interaction between Amlodipine-perindopril and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop perindopril well before the procedure (about 72 hours per labeling) and use another antihypertensive class meanwhile.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Sacubitril / valsartan, Amifostine. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
