Drug interactions
Amlodipine-valsartan + Atogepant
Severity: Minor
Amlodipine-valsartan and Atogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is metabolized mainly by CYP3A4, and amlodipine is a weak CYP3A4 inhibitor, so atogepant exposure may rise slightly. The expected effect is small and unlikely to be clinically significant.
What this interaction means in plain words
Amlodipine-valsartan and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Atogepant belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by amlodipine may slightly reduce atogepant metabolism.
What to do
No dose adjustment is generally required; be aware of possible increased atogepant adverse effects such as constipation or nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Amlodipine-valsartan with Atogepant?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Atogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is metabolized mainly by CYP3A4, and amlodipine is a weak CYP3A4 inhibitor, so atogepant exposure may rise slightly. The expected effect is small and unlikely to be clinically significant.
How serious is the interaction between Amlodipine-valsartan and Atogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; be aware of possible increased atogepant adverse effects such as constipation or nausea.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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