Drug interactions
Amlodipine-valsartan + Carbamazepine
Severity: Moderate
Amlodipine-valsartan and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and can lower amlodipine concentrations, reducing blood pressure control. The suggested OATP1B1 effect on valsartan is not an established clinical concern.
What this interaction means in plain words
Amlodipine-valsartan and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Carbamazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by carbamazepine increases amlodipine metabolism.
What to do
Monitor blood pressure after carbamazepine is started or stopped and increase the amlodipine dose if control is lost. Reassess the dose when carbamazepine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Carbamazepine?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and can lower amlodipine concentrations, reducing blood pressure control. The suggested OATP1B1 effect on valsartan is not an established clinical concern.
How serious is the interaction between Amlodipine-valsartan and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after carbamazepine is started or stopped and increase the amlodipine dose if control is lost. Reassess the dose when carbamazepine is withdrawn.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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