Drug interactions
Amlodipine-valsartan + Clevidipine
Severity: Moderate
Amlodipine-valsartan and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine is a dihydropyridine calcium channel blocker, so combining it with amlodipine duplicates therapy and can cause excessive vasodilation. This may produce marked hypotension and reflex tachycardia.
What this interaction means in plain words
Amlodipine-valsartan and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Clevidipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade in vascular smooth muscle.
What to do
Avoid routine concurrent use; if clevidipine is needed in a patient on amlodipine, titrate it slowly with continuous blood pressure monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Amlodipine-valsartan with Clevidipine?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine is a dihydropyridine calcium channel blocker, so combining it with amlodipine duplicates therapy and can cause excessive vasodilation. This may produce marked hypotension and reflex tachycardia.
How serious is the interaction between Amlodipine-valsartan and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; if clevidipine is needed in a patient on amlodipine, titrate it slowly with continuous blood pressure monitoring.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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