Drug interactions
Amlodipine-valsartan + Dalteparin
Severity: Moderate
Amlodipine-valsartan and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone and cause hyperkalemia. Combined with an ARB the risk is higher, especially in patients with renal impairment, diabetes or prolonged therapy.
What this interaction means in plain words
Amlodipine-valsartan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Heparin-mediated inhibition of adrenal aldosterone synthesis adds to the potassium-retaining effect of valsartan.
What to do
Check serum potassium and renal function when dalteparin is continued beyond a few days. Take extra care in patients with renal impairment or diabetes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Amlodipine-valsartan with Dalteparin?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone and cause hyperkalemia. Combined with an ARB the risk is higher, especially in patients with renal impairment, diabetes or prolonged therapy.
How serious is the interaction between Amlodipine-valsartan and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when dalteparin is continued beyond a few days. Take extra care in patients with renal impairment or diabetes.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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