Drug interactions
Amlodipine-valsartan + Dronedarone
Severity: Moderate
Amlodipine-valsartan and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and can raise amlodipine levels. It also slows sinus and AV node conduction, which can add to calcium channel blocker effects on heart rate, though amlodipine has little nodal action.
What this interaction means in plain words
Amlodipine-valsartan and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by dronedarone increases amlodipine exposure, with possible additive hypotensive and conduction effects.
What to do
Monitor blood pressure, heart rate and ECG when starting dronedarone, and reduce the amlodipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Dronedarone?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP3A4 and can raise amlodipine levels. It also slows sinus and AV node conduction, which can add to calcium channel blocker effects on heart rate, though amlodipine has little nodal action.
How serious is the interaction between Amlodipine-valsartan and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when starting dronedarone, and reduce the amlodipine dose if hypotension or edema occurs.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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