Drug interactions
Amlodipine-valsartan + Eluxadoline
Severity: Moderate
Amlodipine-valsartan and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is reported to inhibit OATP1B1 and may raise eluxadoline concentrations, increasing the risk of its adverse effects such as constipation and pancreatitis.
What this interaction means in plain words
Amlodipine-valsartan and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Inhibition of OATP1B1 reduces hepatic uptake of eluxadoline.
What to do
Consider eluxadoline 75 mg twice daily and monitor for abdominal pain and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Amlodipine-valsartan with Eluxadoline?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan is reported to inhibit OATP1B1 and may raise eluxadoline concentrations, increasing the risk of its adverse effects such as constipation and pancreatitis.
How serious is the interaction between Amlodipine-valsartan and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider eluxadoline 75 mg twice daily and monitor for abdominal pain and constipation.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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