Drug interactions
Amlodipine-valsartan + Eplerenone
Severity: Major
Amlodipine-valsartan and Eplerenone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both valsartan and eplerenone reduce potassium excretion, so the combination markedly increases the risk of hyperkalemia, especially in renal impairment or diabetes. It is used therapeutically in heart failure but requires monitoring.
What this interaction means in plain words
Amlodipine-valsartan and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-valsartan belongs to Cardiovascular; Eplerenone belongs to Cardiovascular.
Why it happens
Additive potassium retention from angiotensin receptor blockade and aldosterone receptor antagonism.
What to do
Check potassium and creatinine at baseline, within the first week, and periodically thereafter; reduce or stop eplerenone if potassium rises above the safe range. Avoid potassium supplements and salt substitutes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Eplerenone?
MediHelp rates the interaction as major. Amlodipine-valsartan and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both valsartan and eplerenone reduce potassium excretion, so the combination markedly increases the risk of hyperkalemia, especially in renal impairment or diabetes. It is used therapeutically in heart failure but requires monitoring.
How serious is the interaction between Amlodipine-valsartan and Eplerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and creatinine at baseline, within the first week, and periodically thereafter; reduce or stop eplerenone if potassium rises above the safe range. Avoid potassium supplements and salt substitutes.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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