Drug interactions
Amlodipine-valsartan + Ethacrynic acid
Severity: Moderate
Amlodipine-valsartan and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid add to the antihypertensive effect of valsartan and amlodipine and can cause volume depletion, hypotension and renal function decline. Potassium loss from the diuretic is partly offset by the ARB.
What this interaction means in plain words
Amlodipine-valsartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through diuresis and RAAS blockade, with first-dose hypotension risk in volume-depleted patients.
What to do
Monitor blood pressure, volume status, electrolytes and creatinine when starting or adjusting therapy, and consider reducing the diuretic dose before starting the ARB.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Amlodipine-valsartan with Ethacrynic acid?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid add to the antihypertensive effect of valsartan and amlodipine and can cause volume depletion, hypotension and renal function decline. Potassium loss from the diuretic is partly offset by the ARB.
How serious is the interaction between Amlodipine-valsartan and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, electrolytes and creatinine when starting or adjusting therapy, and consider reducing the diuretic dose before starting the ARB.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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