Drug interactions
Amlodipine-valsartan + Furosemide
Severity: Moderate
Amlodipine-valsartan and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide causes potassium and volume loss while valsartan retains potassium, so the net effect on potassium is variable. Volume depletion from furosemide can also produce first-dose hypotension and acute kidney injury when valsartan is given.
What this interaction means in plain words
Amlodipine-valsartan and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Loop diuretic-induced kaliuresis and volume depletion oppose and compound the effects of angiotensin receptor blockade on potassium and renal perfusion.
What to do
Monitor serum potassium, creatinine and blood pressure after starting or changing doses, and consider reducing the diuretic dose when starting valsartan in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Amlodipine-valsartan with Furosemide?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide causes potassium and volume loss while valsartan retains potassium, so the net effect on potassium is variable. Volume depletion from furosemide can also produce first-dose hypotension and acute kidney injury when valsartan is given.
How serious is the interaction between Amlodipine-valsartan and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure after starting or changing doses, and consider reducing the diuretic dose when starting valsartan in volume-depleted patients.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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