Drug interactions
Amlodipine-valsartan + Gentamicin
Severity: Moderate
Amlodipine-valsartan and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both gentamicin and angiotensin receptor blockers can impair kidney function, and volume depletion increases that risk. Gentamicin can also cause renal potassium and magnesium wasting while valsartan retains potassium, making electrolyte shifts unpredictable.
What this interaction means in plain words
Amlodipine-valsartan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic risk, as aminoglycoside tubular toxicity combines with ARB-reduced glomerular perfusion pressure.
What to do
Monitor serum creatinine, potassium and magnesium, and gentamicin levels, and consider temporarily holding valsartan if acute kidney injury or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Amlodipine-valsartan with Gentamicin?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both gentamicin and angiotensin receptor blockers can impair kidney function, and volume depletion increases that risk. Gentamicin can also cause renal potassium and magnesium wasting while valsartan retains potassium, making electrolyte shifts unpredictable.
How serious is the interaction between Amlodipine-valsartan and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium, and gentamicin levels, and consider temporarily holding valsartan if acute kidney injury or volume depletion develops.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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