Drug interactions
Amlodipine-valsartan + Iloperidone
Severity: Moderate
Amlodipine-valsartan and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has alpha-1 blocking activity that causes orthostatic hypotension, and antihypertensives can add to this. Dizziness, syncope and falls are possible, especially during titration.
What this interaction means in plain words
Amlodipine-valsartan and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic antagonism and vasodilation or RAAS blockade.
What to do
Monitor orthostatic blood pressure during iloperidone titration and consider reducing antihypertensive doses if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-valsartan and Iloperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Amlodipine-valsartan with Iloperidone?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has alpha-1 blocking activity that causes orthostatic hypotension, and antihypertensives can add to this. Dizziness, syncope and falls are possible, especially during titration.
How serious is the interaction between Amlodipine-valsartan and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure during iloperidone titration and consider reducing antihypertensive doses if symptomatic.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
