Drug interactions
Amlodipine-valsartan + Itraconazole
Severity: Major
Amlodipine-valsartan and Itraconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and can raise amlodipine exposure, leading to hypotension, peripheral edema and reflex tachycardia. Itraconazole also has negative inotropic effects that may add to those of calcium channel blockers and worsen heart failure.
What this interaction means in plain words
Amlodipine-valsartan and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-valsartan belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism, plus additive negative inotropic effects.
What to do
Monitor blood pressure, heart rate and signs of edema or heart failure, and reduce the amlodipine dose if needed. Avoid the combination in patients with heart failure where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-valsartan and Itraconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Itraconazole?
MediHelp rates the interaction as major. Amlodipine-valsartan and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole is a strong CYP3A4 inhibitor and can raise amlodipine exposure, leading to hypotension, peripheral edema and reflex tachycardia. Itraconazole also has negative inotropic effects that may add to those of calcium channel blockers and worsen heart failure.
How serious is the interaction between Amlodipine-valsartan and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of edema or heart failure, and reduce the amlodipine dose if needed. Avoid the combination in patients with heart failure where possible.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
