Drug interactions
Amlodipine-valsartan + Letermovir
Severity: Moderate
Amlodipine-valsartan and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir can raise amlodipine concentrations through CYP3A4 inhibition and may increase valsartan exposure through OATP1B1/3 inhibition. Higher levels may cause hypotension and edema.
What this interaction means in plain words
Amlodipine-valsartan and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4 and hepatic OATP1B1/3 transporters, reducing clearance of amlodipine and valsartan.
What to do
Monitor blood pressure and edema during letermovir therapy. Reduce the doses of the antihypertensives if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Amlodipine-valsartan with Letermovir?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir can raise amlodipine concentrations through CYP3A4 inhibition and may increase valsartan exposure through OATP1B1/3 inhibition. Higher levels may cause hypotension and edema.
How serious is the interaction between Amlodipine-valsartan and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during letermovir therapy. Reduce the doses of the antihypertensives if hypotension develops.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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