Drug interactions
Amlodipine-valsartan + Lomitapide
Severity: Moderate
Amlodipine-valsartan and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and weak CYP3A4 inhibitors such as amlodipine may raise its exposure. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Amlodipine-valsartan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Amlodipine weakly inhibits CYP3A4-mediated metabolism of lomitapide.
What to do
Limit the lomitapide dose to no more than 30 mg daily when given with weak CYP3A4 inhibitors. Monitor liver enzymes as per lomitapide labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Lomitapide?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a sensitive CYP3A4 substrate, and weak CYP3A4 inhibitors such as amlodipine may raise its exposure. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Amlodipine-valsartan and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose to no more than 30 mg daily when given with weak CYP3A4 inhibitors. Monitor liver enzymes as per lomitapide labeling.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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