Drug interactions
Amlodipine-valsartan + Lornoxicam
Severity: Moderate
Amlodipine-valsartan and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam, like other NSAIDs, can blunt the antihypertensive effect of valsartan and increase the risk of renal impairment and hyperkalemia. The risk is highest in elderly, dehydrated or renally impaired patients.
What this interaction means in plain words
Amlodipine-valsartan and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and potassium excretion, opposing angiotensin receptor blockade.
What to do
Use the lowest effective NSAID dose for the shortest time and keep the patient hydrated. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Amlodipine-valsartan with Lornoxicam?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam, like other NSAIDs, can blunt the antihypertensive effect of valsartan and increase the risk of renal impairment and hyperkalemia. The risk is highest in elderly, dehydrated or renally impaired patients.
How serious is the interaction between Amlodipine-valsartan and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and keep the patient hydrated. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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