Drug interactions
Amlodipine-valsartan + Lovastatin
Severity: Minor
Amlodipine-valsartan and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is an OATP1B1 substrate, so inhibitors could raise its exposure, but lovastatin is not a clinically important OATP1B1 inhibitor and no meaningful interaction is established. Lovastatin metabolism is also affected by CYP3A4 inhibitors, though amlodipine is only a weak inhibitor and effects on lovastatin are small.
What this interaction means in plain words
Amlodipine-valsartan and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Lovastatin belongs to Cardiovascular.
Why it happens
Theoretical OATP1B1 competition; no established clinically relevant mechanism.
What to do
No specific action is needed; continue routine monitoring of blood pressure and muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Lovastatin?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is an OATP1B1 substrate, so inhibitors could raise its exposure, but lovastatin is not a clinically important OATP1B1 inhibitor and no meaningful interaction is established. Lovastatin metabolism is also affected by CYP3A4 inhibitors, though amlodipine is only a weak inhibitor and effects on lovastatin are small.
How serious is the interaction between Amlodipine-valsartan and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; continue routine monitoring of blood pressure and muscle symptoms.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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