Drug interactions
Amlodipine-valsartan + Mefenamic acid
Severity: Moderate
Amlodipine-valsartan and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid can reduce the blood pressure lowering effect of valsartan and, in combination with an angiotensin receptor blocker, increases the risk of acute kidney injury and hyperkalemia. The risk is greater in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Amlodipine-valsartan and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and potassium excretion, opposing angiotensin receptor blockade.
What to do
Use the shortest possible NSAID course at the lowest dose with adequate hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Amlodipine-valsartan with Mefenamic acid?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid can reduce the blood pressure lowering effect of valsartan and, in combination with an angiotensin receptor blocker, increases the risk of acute kidney injury and hyperkalemia. The risk is greater in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Amlodipine-valsartan and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest possible NSAID course at the lowest dose with adequate hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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