Drug interactions
Amlodipine-valsartan + Nisoldipine
Severity: Moderate
Amlodipine-valsartan and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and nisoldipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds to hypotension, reflex tachycardia, flushing and peripheral edema without meaningful additional benefit.
What this interaction means in plain words
Amlodipine-valsartan and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade causing vasodilation.
What to do
Avoid using two dihydropyridine calcium channel blockers together; choose one agent and titrate. If both are given, monitor blood pressure and heart rate closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Amlodipine-valsartan with Nisoldipine?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and nisoldipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds to hypotension, reflex tachycardia, flushing and peripheral edema without meaningful additional benefit.
How serious is the interaction between Amlodipine-valsartan and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridine calcium channel blockers together; choose one agent and titrate. If both are given, monitor blood pressure and heart rate closely.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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