Drug interactions
Amlodipine-valsartan + Piroxicam
Severity: Moderate
Amlodipine-valsartan and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam can reduce the blood pressure lowering effect of valsartan by suppressing renal prostaglandins and promoting sodium and water retention. In older or volume-depleted patients it may cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Amlodipine-valsartan and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin-mediated renal vasodilation combined with angiotensin receptor blockade lowers glomerular filtration and antagonizes antihypertensive effect.
What to do
Use the lowest effective NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium; consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Amlodipine-valsartan with Piroxicam?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam can reduce the blood pressure lowering effect of valsartan by suppressing renal prostaglandins and promoting sodium and water retention. In older or volume-depleted patients it may cause acute kidney injury and hyperkalemia.
How serious is the interaction between Amlodipine-valsartan and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium; consider paracetamol as an alternative.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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