Drug interactions
Amlodipine-valsartan + Rosiglitazone
Severity: Minor
Amlodipine-valsartan and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The proposed effect of rosiglitazone on valsartan transport is theoretical with no clear clinical consequence. Both amlodipine and rosiglitazone can cause peripheral edema, and rosiglitazone can cause fluid retention.
What this interaction means in plain words
Amlodipine-valsartan and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Rosiglitazone belongs to Endocrine.
Why it happens
Theoretical OATP1B1 inhibition affecting valsartan; not established clinically.
What to do
No dose adjustment is needed. Monitor for edema and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Amlodipine-valsartan with Rosiglitazone?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The proposed effect of rosiglitazone on valsartan transport is theoretical with no clear clinical consequence. Both amlodipine and rosiglitazone can cause peripheral edema, and rosiglitazone can cause fluid retention.
How serious is the interaction between Amlodipine-valsartan and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for edema and blood pressure.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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