Drug interactions
Amobarbital + Cocaine
Severity: Minor
Amobarbital and Cocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates may speed up cocaine metabolism through enzyme induction. With topical medical cocaine, systemic exposure is small and the effect is unlikely to matter clinically.
What this interaction means in plain words
Amobarbital and Cocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Cocaine belongs to Central Nervous System.
Why it happens
Induction of hepatic enzymes, including CYP2B6 and CYP3A4, may increase cocaine metabolism.
What to do
No specific action is needed; be aware that the anesthetic effect could be marginally shorter.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Amobarbital with Cocaine?
MediHelp rates the interaction as minor. Amobarbital and Cocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates may speed up cocaine metabolism through enzyme induction. With topical medical cocaine, systemic exposure is small and the effect is unlikely to matter clinically.
How serious is the interaction between Amobarbital and Cocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; be aware that the anesthetic effect could be marginally shorter.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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