Drug interactions
Amobarbital + Cyclobenzaprine
Severity: Moderate
Amobarbital and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can cause deeper sedation, dizziness and impaired psychomotor performance. Barbiturates may also induce hepatic enzymes and lower cyclobenzaprine exposure.
What this interaction means in plain words
Amobarbital and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with possible CYP enzyme induction by the barbiturate.
What to do
Start with the lowest effective doses and advise patients to avoid driving or hazardous tasks until response is known. Monitor sedation and reduce doses if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Amobarbital and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can cause deeper sedation, dizziness and impaired psychomotor performance. Barbiturates may also induce hepatic enzymes and lower cyclobenzaprine exposure.
How serious is the interaction between Amobarbital and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and advise patients to avoid driving or hazardous tasks until response is known. Monitor sedation and reduce doses if excessive drowsiness occurs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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