Drug interactions
Amobarbital + Diphenoxylate
Severity: Moderate
Amobarbital and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid, and at higher doses it can add to the sedative effect of barbiturates. Together they may produce drowsiness and, in overdose, respiratory depression.
What this interaction means in plain words
Amobarbital and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from barbiturate GABA-A potentiation and opioid receptor activity.
What to do
Monitor for excessive sedation and respiratory depression and keep diphenoxylate at the labeled dose. Advise patients to avoid driving or hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Amobarbital with Diphenoxylate?
MediHelp rates the interaction as moderate. Amobarbital and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid, and at higher doses it can add to the sedative effect of barbiturates. Together they may produce drowsiness and, in overdose, respiratory depression.
How serious is the interaction between Amobarbital and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression and keep diphenoxylate at the labeled dose. Advise patients to avoid driving or hazardous tasks.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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