Drug interactions
Amobarbital + Docetaxel
Severity: Moderate
Amobarbital and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme induction by amobarbital may reduce docetaxel exposure and potentially its antitumor effect, since docetaxel is cleared by CYP3A4.
What this interaction means in plain words
Amobarbital and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Docetaxel belongs to Oncology.
Why it happens
Induction of CYP3A4 increases docetaxel clearance.
What to do
Prefer a non-inducing sedative or anticonvulsant where possible, and monitor oncologic response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Amobarbital with Docetaxel?
MediHelp rates the interaction as moderate. Amobarbital and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzyme induction by amobarbital may reduce docetaxel exposure and potentially its antitumor effect, since docetaxel is cleared by CYP3A4.
How serious is the interaction between Amobarbital and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing sedative or anticonvulsant where possible, and monitor oncologic response and toxicity.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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