Drug interactions
Amobarbital + Doxylamine
Severity: Moderate
Amobarbital and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, so together they can cause marked drowsiness, slowed reactions and impaired coordination. Risk is higher with alcohol and in older adults.
What this interaction means in plain words
Amobarbital and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depression via GABAergic enhancement and H1 receptor blockade.
What to do
Avoid combining with alcohol, reduce doses where possible and warn patients about driving. Consider a non-sedating alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Amobarbital with Doxylamine?
MediHelp rates the interaction as moderate. Amobarbital and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, so together they can cause marked drowsiness, slowed reactions and impaired coordination. Risk is higher with alcohol and in older adults.
How serious is the interaction between Amobarbital and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with alcohol, reduce doses where possible and warn patients about driving. Consider a non-sedating alternative.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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