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Drug interactions

Amobarbital + Ifosfamide

Severity: Major

Amobarbital and Ifosfamide: major interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Inducers such as amobarbital can increase ifosfamide bioactivation and formation of the neurotoxic and nephrotoxic metabolite chloroacetaldehyde. This may increase toxicity, including encephalopathy, and alter efficacy. Barbiturate sedation may also confound neurotoxicity assessment.

What this interaction means in plain words

Amobarbital and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amobarbital belongs to Central Nervous System; Ifosfamide belongs to Oncology.

Evidence level: Moderate

Why it happens

Barbiturate induction of CYP3A4 and CYP2B6 increases ifosfamide activation and chloroacetaldehyde production.

What to do

Avoid concurrent use if possible. If needed, monitor closely for neurotoxicity, nephrotoxicity and myelosuppression and consider ifosfamide dose adjustment.

What to ask your pharmacist

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Amobarbital with Ifosfamide?

MediHelp rates the interaction as major. Amobarbital and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inducers such as amobarbital can increase ifosfamide bioactivation and formation of the neurotoxic and nephrotoxic metabolite chloroacetaldehyde. This may increase toxicity, including encephalopathy, and alter efficacy. Barbiturate sedation may also confound neurotoxicity assessment.

How serious is the interaction between Amobarbital and Ifosfamide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible. If needed, monitor closely for neurotoxicity, nephrotoxicity and myelosuppression and consider ifosfamide dose adjustment.

What other medicines interact with Amobarbital?

MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.

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